I wonder if it's going to be a halfway comedic take on the characters? The Rhino has been reimagined several times, Giamatti's gotta be right for one of them! Did you catch the most recent episode of Ultimate Spider-man on the Disney channel? It featured the Rhino, but he was a --- - minor spoilers--- -
nerdy kid picked on by Flash Thompson, sort of like Peter Parker himself. He drank a stolen elixir to become the super powerful, but not as smart Rhino. A Jekyll/Hyde origin for the character. Giamatti could rock that kind of Rhino, but then the Rhino would be completely CGI, there's a good chance of that anyway. What do you think, will there actually be a human being in a rhino suit or Hulklike CGI?